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LY 2389575 hydrochloride

LY2389575 hydrochloride is a selective, non-competitive mGlu3 negative allosteric modulator (IC50 = 190 nM) . It is used in Alzheimer's disease research, where it has been shown in experimental models to upregulate Mrc1 and exacerbate β-amyloid toxicity, providing a tool for studying disease mechanisms.

Product Specifications

CAS Number

885104-09-6

Product Name Alternative

βAmyloid, β Amyloid, bAmyloid, Aβ, b Amyloid, BetaAmyloid, Beta Amyloid, LY 2389575 hydrochloride, LY 2389575 Hydrochloride, LY2389575 Hydrochloride, LY-2389575 Hydrochloride, mGluR

Field of Research

Neuroscience

Purity

99.45% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.52 mM) ; DMSO:90 mg/mL (205.21 mM) ; Methanol:7.5 mg/mL (17.1 mM)

Smiles

N (CC1=C (Cl) C=C (Cl) C=C1) [C@@H]2CN (CC2) C=3N=CC (Br) =CN3.Cl

Molecular Formula

C15H16BrCl3N4

Molecular Weight

438.58

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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