LY 2389575 hydrochloride
LY2389575 hydrochloride is a selective, non-competitive mGlu3 negative allosteric modulator (IC50 = 190 nM) . It is used in Alzheimer's disease research, where it has been shown in experimental models to upregulate Mrc1 and exacerbate β-amyloid toxicity, providing a tool for studying disease mechanisms.
Product Specifications
CAS Number
885104-09-6
Product Name Alternative
βAmyloid, β Amyloid, bAmyloid, Aβ, b Amyloid, BetaAmyloid, Beta Amyloid, LY 2389575 hydrochloride, LY 2389575 Hydrochloride, LY2389575 Hydrochloride, LY-2389575 Hydrochloride, mGluR
Field of Research
Neuroscience
Purity
99.45% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.52 mM) ; DMSO:90 mg/mL (205.21 mM) ; Methanol:7.5 mg/mL (17.1 mM)
Smiles
N (CC1=C (Cl) C=C (Cl) C=C1) [C@@H]2CN (CC2) C=3N=CC (Br) =CN3.Cl
Molecular Formula
C15H16BrCl3N4
Molecular Weight
438.58
Storage Conditions
-20°C
Notes
For research use only.
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