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CDK8-IN-12

CDK8-IN-12 is a potent, selective, and orally bioavailable CDK8 inhibitor (Ki: 14 nM) with additional activity against GSK-3α/β and PCK-θ. It demonstrates anti-proliferative effects in MV4-11 leukemia cells and is a valuable chemical probe for researching transcription-dependent cancers and inflammatory diseases in experimental models.

Product Specifications

CAS Number

2613307-67-6

Product Name Alternative

CDK8, CDK8IN12, CDK8-IN-12, GSK3, GSK-3α, GSK-3β

Field of Research

Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.55% (May vary between batches)

Solubility

DMSO:27.5 mg/mL (72.02 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.24 mM)

Smiles

O=C1C2 (CCN (CC2) C=3C (=CN=CC3Cl) C4=CC=5C (O4) =CC=CC5) CCN1

Molecular Formula

C21H20ClN3O2

Molecular Weight

381.86

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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