Glucocorticoid receptor modulator 1

This potent, orally bioavailable small molecule acts as a dual inhibitor of NF-κB and AP-1 signaling pathways, with IC50 values of 9 nM and 130 nM, respectively. It effectively suppresses pro-inflammatory mediators like IL-6, TNF-α, and MMP-13, demonstrating utility for researching inflammatory skin disease models both in vitro and in vivo.