Glucocorticoid receptor modulator 1
This potent, orally bioavailable small molecule acts as a dual inhibitor of NF-κB and AP-1 signaling pathways, with IC50 values of 9 nM and 130 nM, respectively. It effectively suppresses pro-inflammatory mediators like IL-6, TNF-α, and MMP-13, demonstrating utility for researching inflammatory skin disease models both in vitro and in vivo.
Product Specifications
CAS Number
2868357-11-1
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction
Purity
99.79% (May vary between batches)
Solubility
DMSO:80 mg/mL (169.86 mM)
Smiles
O=C (C=1C=CC=CC1) N2C3=CC=C (C=C3CCC2) NS (=O) (=O) C=4C=C (Cl) C (=CC4OC) C
Molecular Formula
C24H23ClN2O4S
Molecular Weight
470.97
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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