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Werner syndrome RecQ helicase-IN-3

Werner syndrome RecQ helicase-IN-3 is a potent, orally bioavailable small molecule inhibitor of the WRN helicase, demonstrating anticancer and antiproliferative effects with an IC50 of 0.06 μM. It serves as a valuable chemical probe for researching DNA damage response and synthetic lethality in microsatellite unstable cancers, applicable in both cellular and animal model studies.

Product Specifications

CAS Number

2869954-98-1

Field of Research

Cell Biology, Molecular Biology

Purity

99.60% (May vary between batches)

Smiles

O=C (C1=NC=CC=C1O) N2CCN (C=3C (=O) N4N=C (N=C4N (C3CC) CC (=O) NC5=CC=C (C=C5Cl) C (F) (F) F) C6=CCOCC6) CC2

Molecular Formula

C31H30ClF3N8O5

Molecular Weight

687.07

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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