(R, R) -Reboxetine mesylate

(R, R) -Reboxetine mesylate is the (R, R) -enantiomer of the selective noradrenaline reuptake inhibitor Reboxetine. This enantiomer exhibits high oral bioavailability and demonstrates greater selectivity with lower affinity for alpha-adrenergic and muscarinic receptors compared to the (S, S) -form, contributing to its utility in neuropharmacology research. It is commonly used in vitro for receptor binding studies and in vivo for animal models investigating depression and noradrenergic function.