JBJ-09-063 hydrochloride

JBJ-09-063 hydrochloride is a potent and mutant-selective EGFR inhibitor, effective against various EGFR mutants including L858R and T790M/C797S with low nM IC50 values. It suppresses downstream signaling (Akt, ERK1/2) and demonstrates anti-tumor activity in both TKI-sensitive and TKI-resistant preclinical models, supporting its use in lung cancer research.