JBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride is a potent and mutant-selective EGFR inhibitor, effective against various EGFR mutants including L858R and T790M/C797S with low nM IC50 values. It suppresses downstream signaling (Akt, ERK1/2) and demonstrates anti-tumor activity in both TKI-sensitive and TKI-resistant preclinical models, supporting its use in lung cancer research.
Product Specifications
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
CN1CCC (CC1) C2=CC=C (C=C2) C3=CC4=C (CN (C4=O) C (C5=C (C=CC (=C5) F) O) C (=O) NC6=NC=CS6) C=C3.Cl
Molecular Formula
C31H30ClFN4O3S
Molecular Weight
593.11
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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