LC kinetic stabilizer-1
LC kinetic stabilizer-1 is a potent and selective small molecule that kinetically stabilizes amyloidogenic immunoglobulin light chain (LC) dimers. It demonstrates EC50 values of 140 nM for WIL-FL and 74.1 nM for the WIL-FLT46L/F49Y variant. This compound is a valuable research tool for investigating light chain amyloidosis (AL) in biochemical and cellular assays.
Product Specifications
CAS Number
2495750-19-9
Smiles
CC=1C=2C (=CC (N (CC) CC) =CC2) OC (=O) C1CCNC (NCC3=CC (=CC=C3) C4=CN=CN4) =O
Molecular Formula
C27H31N5O3
Molecular Weight
473.57
Storage Conditions
-20°C
Notes
For research use only.
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