R 59-022 hydrochloride
R 59-022 hydrochloride is a diacylglycerol kinase (DGK) inhibitor (IC50: 2.8 μM) and 5-HT receptor antagonist that activates PKC. It is used in research to modulate lipid signaling, such as enhancing thrombin-induced diglyceride production in platelets and inhibiting phosphatidic acid formation in neutrophils.
Product Specifications
CAS Number
93076-98-3
Product Name Alternative
R 59-022 Hydrochloride, PKC, 5HTReceptor, 5HT Receptor, 5-HT Receptor, DKGI-I Hydrochloride, DKGI-I hydrochloride, DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride, Diacylglycerol kinase inhibitor I Hydrochloride, Diacylglycerol kinase inhibitor I hydrochloride, DGK
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Purity
97.70% (May vary between batches)
Solubility
DMSO:55 mg/mL (110.88 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.03 mM)
Smiles
Cl.O=C1C (=C (N=C2SC=CN21) C) CCN3CCC (=C (C=4C=CC=CC4) C5=CC=C (F) C=C5) CC3
Molecular Formula
C27H27ClFN3OS
Molecular Weight
496.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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