KRAS G12C inhibitor 48
KRAS G12C Inhibitor 48 is a potent small molecule targeting the KRAS G12C mutation with an IC50 of 639.91 nM. It demonstrates antiproliferative activity in vitro, with IC50 values of 0.796 μM, 6.33 μM, and 16.14 μM in H358, H23, and A549 cell lines, respectively. This inhibitor is a valuable tool for oncology research, supporting studies on mutant KRAS-driven cancers in cellular and biochemical assays.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
CN1CCC[C@H]1COC2=NC3=C (CCN (C3) C4=CC=CC5=C4C (=CC=C5) Cl) C (=N2) N6CCN ([C@H] (C6) CC#N) C (=O) /C (=C/C7CC7) /C#N
Molecular Formula
C36H39ClN8O2
Molecular Weight
651.2
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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