MTK458
MTK458 (EP-0035985) is an orally bioavailable, brain-penetrant small molecule activator of PINK1. It promotes the clearance of pathological alpha-synuclein in preclinical models, such as the PFF inoculation model, by stabilizing the PINK1/TOM complex. This compound is a valuable research tool for investigating Parkinson's disease mechanisms and potential therapeutic strategies.
Product Specifications
CAS Number
2499962-58-0
Product Name Alternative
Mitophagy activator 1, EP-0035985, PTEN-induced kinase 1 (PINK1)
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Purity
98.36% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (9.93 mM) ; DMSO:80 mg/mL (240.73 mM)
Smiles
N (C1=C2C (NC (C (F) (F) F) =C2) =NC=N1) [C@H]3C=4C (CCC3) =CC=CC4
Molecular Formula
C17H15F3N4
Molecular Weight
332.32
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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