BOLD-100 free base
BOLD-100 (NKP-1339/IT-139) is a ruthenium-based compound that disrupts ER homeostasis by inhibiting stress-induced GRP78 upregulation. This action triggers ER stress and the UPR, perturbing the crosstalk between ER stress, lysosomes, and autophagy. It is used in cancer research, demonstrating antitumor activity in both in vitro and in vivo models.
Product Specifications
CAS Number
783324-98-1
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Smiles
[Cl-][Ru+4] ([Cl-]) ([Cl-]) ([Cl-]) ([N]1=CC=2C=CC=CC2N1) [N]3=CC=4C=CC=CC4N3
Molecular Formula
C14H12Cl4N4Ru
Molecular Weight
479.15
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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