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VEGFR-2/BRAF-IN-1

VEGFR-2/BRAF-IN-1 is a potent dual kinase inhibitor targeting VEGFR-2 and both wild-type and V600E mutant BRAF, with IC50 values in the nanomolar range. It induces apoptosis and G1/S phase cell cycle arrest, supporting its use in cancer research for in vitro mechanistic studies and in vivo models of angiogenesis and tumor growth.

Product Specifications

Field of Research

Cardiovascular Research, Cardiovascular Research; Cell Biology, Cell Biology, Signal Transduction

Smiles

C1CCC2=C (C1) C3=C (S2) N=C (N (C3=O) C4=CC=C (C=C4) Cl) SCC (=O) NNC (=O) NC5=CC (=C (C=C5) Cl) C (F) (F) F

Molecular Formula

C26H20Cl2F3N5O3S2

Molecular Weight

642.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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