GCGR antagonist 2
GCGR Antagonist 2 is a potent, orally bioavailable furan-2-carbohydrazide glucagon receptor antagonist. It binds the human receptor with a Kd of 2.3 nM and inhibits rat receptor activity with an IC50 of 0.43 nM, effectively blocking glucagon-stimulated glycogenolysis. This compound is a valuable tool for studying glucose metabolism in diabetes research, applicable in both in vitro binding assays and in vivo metabolic studies.
Product Specifications
CAS Number
280134-25-0
Field of Research
Pharmacology & Drug Discovery
Smiles
C (N1C=2C (=C (C=NNC (=O) C3=CC (C#N) =C (O) C=C3) C=CC2) C=C1) C4=C (C) C (C) =CC (C) =C4C
Molecular Formula
C28H26N4O2
Molecular Weight
450.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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