NMDAR/TRPM4-IN-2
NMDAR/TRPM4-IN-2 is a potent, small-molecule interfacial inhibitor that disrupts the NMDAR/TRPM4 complex. It demonstrates significant neuroprotective efficacy in models of ischemic stroke (MCAO) and excitotoxicity, protecting against brain damage, retinal ganglion cell loss, and hippocampal neuronal cell death and mitochondrial dysfunction in vitro with an IC50 of 2.1 μM.
Product Specifications
CAS Number
2243506-33-2
Product Name Alternative
ERK, iGluR, NMDA receptor, TRPVChannel, TRPV Channel, TRPChannel, TRPM4, TRP Channel
Field of Research
Neuroscience, Neuroscience; Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.77% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.12 mM) ; DMSO:112.5 mg/mL (340.81 mM) ; H2O:90 mg/mL (272.65 mM)
Smiles
Cl.Cl.CCN (CCN) Cc1cccc (Br) c1
Molecular Formula
C11H19BrCl2N2
Molecular Weight
330.092
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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