PD-1/PD-L1-IN-13
PD-1/PD-L1-IN-13 is a potent small molecule inhibitor of the PD-1/PD-L1 immune checkpoint, demonstrating an IC50 of 10.2 nM. It enhances CD8+ T-cell activation in vitro and has shown efficacy in delaying tumor growth in murine Hepa1-6 hepatocellular carcinoma models, supporting its use in immuno-oncology research.
Product Specifications
Field of Research
Cancer Biology; Immunology & Inflammation
Smiles
CC1=C (C=CC=C1C (OC2=C (C=C (C (=C2) OCC3=CC (=NC=C3) C#N) CN[C@H]4[C@H] ([C@@H] ([C@H] (OC4O) CO) O) O) Cl) (F) F) C5=CC6=C (C=C5) OCCO6
Molecular Formula
C36H34ClF2N3O9
Molecular Weight
726.12
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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