Keap1-Nrf2-IN-11
Keap1-Nrf2-IN-11 (Compound 6k) is a potent, high-affinity Keap1-Nrf2 inhibitor (KD = 0.21 nM) that promotes Nrf2 nuclear translocation to suppress ROS, NO, and TNF-α production. This mechanism supports its application in cellular and animal models for studying inflammatory and oxidative stress-related pathways.
Product Specifications
CAS Number
2796292-75-4
Field of Research
Cancer Biology, Immunology & Inflammation, Signal Transduction
Smiles
CCN1CCN (CC1) CCC (=O) NC2=CC=C (C=C2) S (=O) (=O) N (CC (=O) N) C3=CC=C (C4=CC=CC=C43) N (CC (=O) N) S (=O) (=O) C5=CC=C (C=C5) OC
Molecular Formula
C36H43N7O8S2
Molecular Weight
765.9
Storage Conditions
-20°C
Notes
For research use only.
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