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PD-1/PD-L1-IN-29

PD-1/PD-L1-IN-29 (S4-1) is a potent small molecule PD-1/PD-L1 interaction inhibitor with an IC50 of 6.1 nM. It induces PD-L1 dimerization and internalization, relocalizing it to the endoplasmic reticulum. This mechanism disrupts the immunosuppressive PD-1/PD-L1 axis, demonstrating anticancer activity in research models for immuno-oncology.

Product Specifications

CAS Number

2665734-13-2

Field of Research

Cancer Biology; Immunology & Inflammation, Cell Biology, Immunology & Inflammation

Smiles

O=C1N (C (=O) C=2C1=CC (CN[C@H] (C (O) =O) CO) =C (OC) C2) C3=C (C) C (=CC=C3) C4=CC=CC=C4

Molecular Formula

C26H24N2O6

Molecular Weight

460.48

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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