PD-1/PD-L1-IN-29

PD-1/PD-L1-IN-29 (S4-1) is a potent small molecule PD-1/PD-L1 interaction inhibitor with an IC50 of 6.1 nM. It induces PD-L1 dimerization and internalization, relocalizing it to the endoplasmic reticulum. This mechanism disrupts the immunosuppressive PD-1/PD-L1 axis, demonstrating anticancer activity in research models for immuno-oncology.