PD-1/PD-L1-IN-29
PD-1/PD-L1-IN-29 (S4-1) is a potent small molecule PD-1/PD-L1 interaction inhibitor with an IC50 of 6.1 nM. It induces PD-L1 dimerization and internalization, relocalizing it to the endoplasmic reticulum. This mechanism disrupts the immunosuppressive PD-1/PD-L1 axis, demonstrating anticancer activity in research models for immuno-oncology.
Product Specifications
CAS Number
2665734-13-2
Field of Research
Cancer Biology; Immunology & Inflammation, Cell Biology, Immunology & Inflammation
Smiles
O=C1N (C (=O) C=2C1=CC (CN[C@H] (C (O) =O) CO) =C (OC) C2) C3=C (C) C (=CC=C3) C4=CC=CC=C4
Molecular Formula
C26H24N2O6
Molecular Weight
460.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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