SHP2/CDK4-IN-1

SHP2/CDK4-IN-1 is a potent, orally active dual inhibitor of SHP2 (IC50=4.3 nM) and CDK4 (IC50=18.2 nM) . It induces cell cycle arrest and inhibits proliferation in TNBC cells, demonstrating significant in vivo antitumor efficacy in syngeneic mouse models, making it a valuable tool for triple-negative breast cancer research.