(R) -Afatinib
(R) -Afatinib is the (R) -enantiomer of Afatinib, functioning as a potent, irreversible inhibitor of the ErbB family (EGFR/HER2) . It exhibits low nanomolar IC50 values against various EGFR mutants and HER2. This compound is a research tool for studying cancers such as NSCLC, ESCC, and gastric cancer in both in vitro and in vivo models.
Product Specifications
CAS Number
439081-17-1
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
N (C=1C2=C (C=C (O[C@@H]3CCOC3) C (NC (C=CCN (C) C) =O) =C2) N=CN1) C4=CC (Cl) =C (F) C=C4
Molecular Formula
C24H25ClFN5O3
Molecular Weight
485.94
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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