EIF4A3-IN-18
EIF4A3-IN-18 is a potent silvestrol analog that inhibits protein synthesis by disrupting eIF4F complex formation, with EC50 values in the low nanomolar range against various cellular targets. It exhibits significant cytotoxicity, particularly against cancer cell lines such as MBA-MB-231 and RMPI-8226, making it a valuable chemical probe for studying translation initiation in cancer pathogenesis research.
Product Specifications
CAS Number
1402931-84-3
Field of Research
Cell Biology
Smiles
O[C@]12[C@] ([C@@H] ([C@@H] (C (N (C) C) =O) [C@H]1O) C3=CC=CC=C3) (OC=4C2=C (OC) C=C (C#N) C4) C5=CC=C (OC) C=C5
Molecular Formula
C29H28N2O6
Molecular Weight
500.54
Storage Conditions
-20°C
Notes
For research use only.
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