Zidesamtinib
Zidesamtinib (NVL-520) is a brain-penetrant, oral inhibitor selectively targeting ROS1 fusions and resistant mutants like G2032R. It is a research tool for investigating non-small cell lung cancer and other solid tumors, with utility demonstrated in both in vitro and in vivo preclinical studies.
Product Specifications
CAS Number
2739829-00-4
Product Name Alternative
ROSKinase, ROS1, ROS Kinase, Zidesamtinib, NVL 520, NVL520, NVL-520
Field of Research
Signal Transduction
Purity
99.74% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:1.5 mg/mL (3.58 mM) ; DMSO:30 mg/mL (71.52 mM)
Smiles
C (C) N1C2=C (CC=3C (C=4C ([C@@H] (C) OC=5C=C2C=NC5N) =CC (F) =CC4) =NN (C) N3) C=N1
Molecular Formula
C22H22FN7O
Molecular Weight
419.455
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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