SIRT2-IN-11
SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor (IC50 = 18.5 μM) that promotes p53 acetylation and upregulates pro-apoptotic targets like CDKN1A, PUMA, and NOXA, leading to p53-dependent apoptosis. It is a useful research tool for investigating p53-mediated pathways in cancer biology, with applications in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1005095-06-6
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Smiles
O=C (N) C1=CC=C2NC (C=3C=CC=CC3) C4C (C2=C1) C5CCC4C5
Molecular Formula
C21H22N2O
Molecular Weight
318.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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