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EIF4A3-IN-9

EIF4A3-IN-9 is a silvestrol analog that inhibits translation by disrupting eIF4F complex assembly, with EC50 values of 29, 450, and 80 nM against myc-LUC, tub-LUC, and MDA-MB-231 cell growth, respectively. It is a valuable chemical probe for studying oncogenic translation and cancer pathogenesis in cellular models.

Product Specifications

CAS Number

1402931-71-8

Field of Research

Cell Biology

Smiles

O[C@]12[C@] ([C@@H] ([C@@H] (C (OC) =O) [C@H]1O) C3=CC=CC=C3) (OC=4C2=C (OC) C=C (C (N) =O) C4) C5=CC=C (OC) C=C5

Molecular Formula

C28H27NO8

Molecular Weight

505.52

Storage Conditions

-20°C

Notes

For research use only.

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