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THRX-144644

THRX-144644 is a potent and lung-restricted ALK5 inhibitor with an IC50 of 0.14 nM. Its localized action mitigates systemic TGFβ pathway toxicities, making it a valuable tool for investigating pulmonary fibrosis and other lung diseases in both in vitro and in vivo models.

Product Specifications

CAS Number

2442519-59-5

Field of Research

Stem Cell & Developmental Biology

Smiles

FC1=C (C=2C (=CNN2) C3=NC4=C (C=C3) N=CC (NCCN5CCN (C (C) C) CC5) =C4) C=C (Cl) C (F) =C1

Molecular Formula

C26H28ClF2N7

Molecular Weight

512

Storage Conditions

-20°C

Notes

For research use only.

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