THRX-144644
THRX-144644 is a potent and lung-restricted ALK5 inhibitor with an IC50 of 0.14 nM. Its localized action mitigates systemic TGFβ pathway toxicities, making it a valuable tool for investigating pulmonary fibrosis and other lung diseases in both in vitro and in vivo models.
Product Specifications
CAS Number
2442519-59-5
Field of Research
Stem Cell & Developmental Biology
Smiles
FC1=C (C=2C (=CNN2) C3=NC4=C (C=C3) N=CC (NCCN5CCN (C (C) C) CC5) =C4) C=C (Cl) C (F) =C1
Molecular Formula
C26H28ClF2N7
Molecular Weight
512
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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