PARP1-IN-12
PARP1-IN-12 is a highly potent PARP1 inhibitor (IC50 = 2.99 nM) with robust antiproliferative activity. It induces apoptosis, G2/M phase cell cycle arrest, and promotes DNA double-strand breaks in BRCA-deficient cells, making it a valuable tool for oncology research in both in vitro and in vivo models of homologous recombination deficiency.
Product Specifications
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Smiles
C[C@H]1CCC[C@@]2 (C) C1=CC3C (OC (C3CNCCCCCCCC (N4CCN (C (C5=C (F) C=CC (CC6=NNC (C7C6C=CC=C7) =O) =C5) =O) CC4) =O) =O) C2
Molecular Formula
C43H56FN5O5
Molecular Weight
741.93
Storage Conditions
-20°C
Notes
For research use only.
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