Talotrexin
Talotrexin (PT523) is a nonpolyglutamatable antifolate analog that potently and selectively inhibits the Reduced Folate Carrier (RFC) . Its primary mechanism involves targeting dihydrofolate reductase (DHFR), making it a valuable research tool for studying antifolate resistance and evaluating antitumor activity in both cellular and animal models.
Product Specifications
CAS Number
113857-87-7
Field of Research
Cell Biology, Metabolism Research, Molecular Biology
Smiles
NC=1C2=C (N=CC (CNC3=CC=C (C (N[C@@H] (CCCNC (=O) C4=C (C (O) =O) C=CC=C4) C (O) =O) =O) C=C3) =N2) N=C (N) N1
Molecular Formula
C27H27N9O6
Molecular Weight
573.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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VP 776-13-75 10/PK
STIR ELEMENT, CYLINDER, AlNiCo Magnet, 5.5MGO, Encapsulated with Isostatically Molded, FDA Approved, Pure PTFE, 13.0mm Diameter, 75.0mm Length, 260°C Max Operating Temp for Coating
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