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Talotrexin

Talotrexin (PT523) is a nonpolyglutamatable antifolate analog that potently and selectively inhibits the Reduced Folate Carrier (RFC) . Its primary mechanism involves targeting dihydrofolate reductase (DHFR), making it a valuable research tool for studying antifolate resistance and evaluating antitumor activity in both cellular and animal models.

Product Specifications

CAS Number

113857-87-7

Field of Research

Cell Biology, Metabolism Research, Molecular Biology

Smiles

NC=1C2=C (N=CC (CNC3=CC=C (C (N[C@@H] (CCCNC (=O) C4=C (C (O) =O) C=CC=C4) C (O) =O) =O) C=C3) =N2) N=C (N) N1

Molecular Formula

C27H27N9O6

Molecular Weight

573.56

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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