EGFR-IN-23

EGFR-IN-23 (Compound 8 from WO2021244502A1) is a potent and selective EGFR tyrosine kinase inhibitor. It exhibits significant activity against the EGFR-DEL19/T790M/C797S triple mutant, with an IC50 of 8.05 nM in BaF3 cellular assays. This inhibitor is a valuable research tool for studying resistant non-small cell lung cancer (NSCLC) in both in vitro and in vivo models.