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EGFR-IN-23

EGFR-IN-23 (Compound 8 from WO2021244502A1) is a potent and selective EGFR tyrosine kinase inhibitor. It exhibits significant activity against the EGFR-DEL19/T790M/C797S triple mutant, with an IC50 of 8.05 nM in BaF3 cellular assays. This inhibitor is a valuable research tool for studying resistant non-small cell lung cancer (NSCLC) in both in vitro and in vivo models.

Product Specifications

CAS Number

2747133-37-3

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Smiles

N (C1=CC (=C (C=C1OC) N2CCC (CN3CCCOCC3) CC2) C=4C=NN (C) C4) C=5N=C (NC6=C (P (C) (C) =O) C7=C (C=C6) N=CC=N7) C (Br) =CN5

Molecular Formula

C36H44BrN10O3P

Molecular Weight

775.68

Storage Conditions

-20°C

Notes

For research use only.

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