(R) -HH2853
(R) -HH2853 is a potent and selective EZH2 inhibitor, demonstrating sub-100 nM IC50 against the EZH2-Y641F mutant. This compound exhibits antitumor activity in preclinical models and is a valuable research tool for studying epigenetics in cancer and autoimmune disease contexts, both in vitro and in vivo.
Product Specifications
CAS Number
2202678-06-4
Product Name Alternative
EZH2, HistoneMethyltransferase, Histone Methyltransferase
Field of Research
Epigenetics & Chromatin
Purity
97.14% (May vary between batches)
Smiles
[C@@H] (C) (C=1N2C (=C (C=C2) C3=CC=C (C) N=N3) C=C (C (NCC4=C (OC) C=C (C) NC4=O) =O) C1C) N5CCN (CC (F) (F) F) CC5
Molecular Formula
C31H36F3N7O3
Molecular Weight
611.66
Storage Conditions
-20°C
Notes
For research use only.
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