TrxR-IN-4

TrxR-IN-4 (Compound 1b) is a potent thioredoxin reductase inhibitor that triggers endoplasmic reticulum stress-mediated apoptosis in HepG2 cells. It has demonstrated hepatoprotective effects in a CCl4-induced liver injury model by downregulating TrxR and suppressing inflammatory responses, supporting research in oncology and hepatotoxicity.