TBK1-IN-1
TBK1-IN-1 is a potent and selective inhibitor of TANK-binding kinase 1 (TBK1), demonstrating an IC50 of 22.4 nM. It suppresses downstream TBK1 signaling, including the expression of cxcl10 and ifnβ, and is a valuable chemical probe for studying TBK1's role in oncology, immunology, and inflammatory disease research in cellular models.
Product Specifications
CAS Number
3031785-78-8
Product Name Alternative
IkB, IkB/IKK, IKK, IκB, TBK1
Field of Research
Signal Transduction
Purity
99.81% (May vary between batches)
Solubility
DMSO:80 mg/mL (162.72 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.71 mM)
Smiles
O=C (NCCCN1CCC2=CN=C (NC3=CC=CC (CN4CCN (C (C) =O) CC4) =C3) N=C21) C5CCC5
Molecular Formula
C27H37N7O2
Molecular Weight
491.63
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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