JAK-IN-24
JAK-IN-24 is a potent JAK inhibitor, demonstrating ATP-competitive inhibition with IC50 values of 0.534 nM and 24 nM at 4 μM and 1 mM ATP, respectively, and an IC50 of 86.171 nM against IL-15-induced STAT5 phosphorylation in PBMCs. This compound is a valuable tool for investigating JAK/STAT signaling in immunological and oncological research contexts, both in vitro and in vivo.
Product Specifications
CAS Number
2042629-43-4
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
N (C1=C2C (NC=C2CCOCC#C) =NC=N1) [C@H]3CN (C (C=C) =O) [C@@H] (C) CC3
Molecular Formula
C20H25N5O2
Molecular Weight
367.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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