PV-1019
PV-1019 (NSC 744039) is a potent and selective Chk2 inhibitor with an IC50 of 24 nM. It blocks Topotecan-induced Chk2 autophosphorylation and IR-induced apoptosis, making it a valuable chemical probe for studying DNA damage response pathways in both cellular and animal models of cancer research.
Product Specifications
CAS Number
1093793-05-5
Field of Research
Cell Biology
Smiles
N (=O) (=O) C1=C2C (C=C (C (NC3=CC=C (C (=NNC (=N) N) C) C=C3) =O) N2) =CC=C1
Molecular Formula
C18H17N7O3
Molecular Weight
379.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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