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PV-1019

PV-1019 (NSC 744039) is a potent and selective Chk2 inhibitor with an IC50 of 24 nM. It blocks Topotecan-induced Chk2 autophosphorylation and IR-induced apoptosis, making it a valuable chemical probe for studying DNA damage response pathways in both cellular and animal models of cancer research.

Product Specifications

CAS Number

1093793-05-5

Field of Research

Cell Biology

Smiles

N (=O) (=O) C1=C2C (C=C (C (NC3=CC=C (C (=NNC (=N) N) C) C=C3) =O) N2) =CC=C1

Molecular Formula

C18H17N7O3

Molecular Weight

379.37

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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