DN-1289
DN-1289 is a potent, brain-penetrant, and selective small molecule inhibitor of DLK (IC50=17 nM) and LZK (IC50=40 nM) . It has demonstrated in vivo efficacy by significantly reducing p-c-Jun levels following optic nerve crush, supporting its research use in studying neuronal injury and degeneration pathways.
Product Specifications
Product Name Alternative
DLK, DNAAlkylation, DNA Alkylation
Field of Research
Molecular Biology, Signal Transduction
Purity
98.56% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.53 mM) ; DMSO:55 mg/mL (124.61 mM)
Smiles
NC1=C (OC (F) F) N=C (C2=NC (N3[C@@H]4CO[C@H] (C3) C4) =NC (N5CC (F) (CC5) F) =C2) C=N1
Molecular Formula
C18H19F4N7O2
Molecular Weight
441.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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