MK-8189
MK-8189 is a highly potent and selective pyrimidine-based inhibitor of PDE10A, exhibiting a Ki of 0.029 nM. This compound is a valuable research tool for investigating PDE10A's role in neurobiology, with applications in preclinical in vitro and in vivo studies relevant to schizophrenia and related CNS disorders.
Product Specifications
CAS Number
1424371-93-6
Product Name Alternative
MK8189
Field of Research
Metabolism Research
Purity
99.38% (May vary between batches)
Solubility
DMSO:100 mg/mL (261.45 mM)
Smiles
C (OC=1C=C (NCC2=NN=C (C) S2) N=C (C) N1) [C@@H]3[C@H] (C3) C4=CC=C (C) C=N4
Molecular Formula
C19H22N6OS
Molecular Weight
382.48
Storage Conditions
-20°C
Notes
For research use only.
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