YLT-11
YLT-11 is a highly selective and orally bioavailable PLK4 inhibitor with a Kd of 5.2 nM, demonstrating potent antiproliferative effects. It induces G2/M arrest and apoptosis in vitro and has shown efficacy in in vivo xenograft models, supporting its use in cancer research, particularly for studying centrosome amplification and tumorigenesis.
Product Specifications
Field of Research
Cell Biology
Smiles
CC (=O) NC1=NC=CC (=N1) C2=CC3=C (C=C2) C (=NN3) /C=C/C4=CC=C (C=C4) CN (C) C
Molecular Formula
C24H24N6O
Molecular Weight
412.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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