ABD957
ABD957 is a potent, selective covalent inhibitor of the ABHD17 depalmitoylase family with an IC50 of 0.21 μM against ABHD17B. It blocks N-Ras signaling and suppresses the growth of NRAS-mutant acute myeloid leukemia cells in vitro, making it a valuable tool for studying depalmitoylation and oncogenic Ras pathways.
Product Specifications
CAS Number
3007772-60-0
Field of Research
Metabolism Research
Smiles
C[C@H]1CN (CCN1C (=O) N2C=CC (=N2) S (=O) (=O) N (C) C) CC3=C (C=C (C=C3) C (F) (F) F) N4C5CCC4CN (C5) CC (=O) O
Molecular Formula
C27H36F3N7O5S
Molecular Weight
627.68
Storage Conditions
-20°C
Notes
For research use only.
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