Nec-3a
Nec-3a is a potent small molecule inhibitor of RIP1 kinase, exhibiting an IC50 of 0.44 μM by blocking its autophosphorylation. This tool compound is widely used in vitro and in vivo to investigate necroptosis and inflammatory pathways in disease models.
Product Specifications
CAS Number
1504558-72-8
Field of Research
Cell Biology, Signal Transduction
Smiles
C (CO) (=O) N1[C@@H] ([C@]2 (C (=N1) C=3C (CC2) =CC=C (OC) C3) [H]) C4=CC (F) =C (OC (F) (F) F) C=C4
Molecular Formula
C21H18F4N2O4
Molecular Weight
438.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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