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Nec-3a

Nec-3a is a potent small molecule inhibitor of RIP1 kinase, exhibiting an IC50 of 0.44 μM by blocking its autophosphorylation. This tool compound is widely used in vitro and in vivo to investigate necroptosis and inflammatory pathways in disease models.

Product Specifications

CAS Number

1504558-72-8

Field of Research

Cell Biology, Signal Transduction

Smiles

C (CO) (=O) N1[C@@H] ([C@]2 (C (=N1) C=3C (CC2) =CC=C (OC) C3) [H]) C4=CC (F) =C (OC (F) (F) F) C=C4

Molecular Formula

C21H18F4N2O4

Molecular Weight

438.37

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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