I-138
I-138 is a potent, cell-permeable inhibitor of the USP1-UAF1 deubiquitinase complex. It promotes the mono-ubiquitination of FANCD2 and PCNA, key DNA damage response proteins, and blocks USP1 auto-processing. This compound is a valuable tool for studying DNA repair pathways, replication stress, and the Fanconi anemia network in cellular models.
Product Specifications
CAS Number
2098211-50-6
Product Name Alternative
USP1-UAF1
Field of Research
Cell Biology, Molecular Biology, Protein Biochemistry
Purity
99.41% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.7 mM) ; DMSO:80 mg/mL (162.44 mM)
Smiles
C (N1C=2C (NC1=O) =CN=C (N2) C3=C (C (C) C) C=CC=C3) C4=CC=C (C=C4) C5=NC (C (F) (F) F) =CN5C
Molecular Formula
C26H23F3N6O
Molecular Weight
492.5
Storage Conditions
-20°C
Notes
For research use only.
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