ZT55
ZT55 is a potent and orally bioavailable JAK2 inhibitor (IC50=0.031 μM) effective against JAK2 V617F-driven pathologies. It demonstrates robust anti-proliferative, pro-apoptotic, and cell cycle arrest activity in HEL cells and suppresses tumor growth in HEL xenograft mouse models, supporting research for myeloproliferative neoplasms like polycythemia vera.
Product Specifications
CAS Number
2138488-38-5
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
C (C (NC1=C (OC) C=CC=C1) =O) C=2C=3C (N (O) C2) =CC=CC3
Molecular Formula
C17H16N2O3
Molecular Weight
296.32
Storage Conditions
-20°C
Notes
For research use only.
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