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O-Desmethyl gefitinib

O-Desmethyl gefitinib is a pharmacologically active metabolite of gefitinib, formed via CYP2D6 metabolism. It acts as an EGFR inhibitor with an IC50 of 36 nM in biochemical assays. This compound is used in research to study drug metabolism, EGFR signaling pathways, and resistance mechanisms in both cellular and animal models of cancer.

Product Specifications

CAS Number

847949-49-9

Product Name Alternative

CYP2D6, HER1, Inhibitor, Gefitinib, human, Epidermal growth factor receptor, EGFR, ErbB-1, O Desmethyl gefitinib, ODesmethyl gefitinib, O-Desmethyl gefitinib, inhibit, plasma

Field of Research

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Purity

97.17% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.62 mM) ; DMSO:27.5 mg/mL (63.53 mM)

Smiles

Oc1cc2ncnc (Nc3ccc (F) c (Cl) c3) c2cc1OCCCN1CCOCC1

Molecular Formula

C21H22ClFN4O3

Molecular Weight

432.88

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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